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Sekisui XenoTech
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Image Search Results
Journal: Journal of Food and Drug Analysis
Article Title: Untargeted metabolomics analysis assisted by signal selection for comprehensively identifying metabolites of new psychoactive substances: 4-MeO-α-PVP as an example
doi: 10.38212/2224-6614.3447
Figure Lengend Snippet: Analytical approach. One NPS, 4-MeO-α-PVP, with different concentration were incubated with human liver S9 followed by LC-MS analysis. Features in the raw LC-MS files were identified by Progenesis QI software. Matched features were further submitted to statistical analysis by using a web tool, MetaboFinder. Differentially expressed features were filtered out and identified by targeted LC-MS/MS analysis.
Article Snippet: Pooled
Techniques: Concentration Assay, Incubation, Liquid Chromatography with Mass Spectroscopy, Software
Journal: Environmental Health Perspectives
Article Title: Characterizing the Peroxisome Proliferator-Activated Receptor (PPAR γ ) Ligand Binding Potential of Several Major Flame Retardants, Their Metabolites, and Chemical Mixtures in House Dust
doi: 10.1289/ehp.1408522
Figure Lengend Snippet: Competitive PPARγ binding potency of rat liver S9 control, DEHP, MIX SRM 2585, and seven other dust samples (100 mg) by incubation with either S9 or inactive S9 fraction (1 mg protein/mL) in a final volume of 3 mL. All data were normalized to the mP of S9 control. MIX includes 5 μM each of FM550, ITP, BDE‑47, BDE‑99, and DEHP. SRM1 and SRM2 represent the incubation of SRM 2585 with rat liver S9 and human liver S9, respectively. The dosing concentrations were 100 μM for DEHP, 2 μM for MIX, 3 mg DEQ/mL for SRM1 and SRM2, and 6 mg DEQ/mL for other dust samples. Values shown are the mean ± SD of the triplicates; samples without error bars represent only one incubated sample. * p < 0.05. ** p < 0.01.
Article Snippet: To compare the bioactivation difference between rodents and humans, we used a pooled
Techniques: Binding Assay, Incubation